It isn't news that running back and reigning Offensive Player of the Year Christian McCaffrey is a key cog in the 49ers' ...

As long as Kyle Shanahan is their coach and they're packed with superstars like Fred Warner, Nick Bosa, and George Kittle, ...

The San Francisco 49ers and fantasy football managers won't have star wide receiver Brandon Aiyuk at their disposal anytime soon following his knee injury.

Following the significant losses of players due to injury and illness, including Brandon Aiyuk, San Francisco 49ers head ...

And yet Kyle Shanahan treated it like he treats all games: He played not to lose. So the 49ers lost.

Already missing star running back Christian McCaffrey to Achilles tendinitis in both his calves, the team also lost star wideouts Deebo Samuel and Brandon Aiyuk during Sunday's 28-18 loss to the ...

The first year of Aiyuk's $120 million four-year contract extension, which was marked by a long dispute with the 49ers, ...

The San Francisco 49ers were hit with a double dose of rough health news regarding two wide receivers on Monday. First, the ...

SAN FRANCISCO - 49ers wide-receiver Brandon Aiyuk is out for the season, according to the team. The team's head coach Kyle ...

San Francisco 49ers receiver Deebo Samuel attempted to play through an illness during Sunday's loss to the Kansas City Chiefs ...

San Francisco 49ers star wide receiver Deebo Samuel attempted to give it a go Sunday against the Kansas City Chiefs. He's ...

Kyle Shanahan on Monday gave several injury updates from the 49ers' loss to the Kansas City Chiefs, as well updates on ...