It isn’t news that running back and reigning Offensive Player of the Year Christian McCaffrey is a key cog in the 49ers’ ...

Following the significant losses of players due to injury and illness, including Brandon Aiyuk, San Francisco 49ers head ...

And yet Kyle Shanahan treated it like he treats all games: He played not to lose. So the 49ers lost.

The news around wide receiver Brandon Aiyuk's season-ending knee injury during the San Francisco 49ers' 28-18 loss to the ...

The strength of the San Francisco 49ers’ offense the past few seasons has been the number of dynamic playmakers that makes it ...

San Francisco 49ers star wide receiver Deebo Samuel attempted to give it a go Sunday against the Kansas City Chiefs. He's ...

San Francisco 49ers receiver Deebo Samuel attempted to play through an illness during Sunday's loss to the Kansas City Chiefs ...

The Niners offense is dealing with another blow as star WR Deebo Samuel has been hospitalized due to pneumonia and fluid in ...

Things didn’t go to plan for the San Francisco 49ers in their highly-anticipated Super Bowl rematch against the Kansas City ...

Brandon Aiyuk suffered a torn ACL and MCL in Sunday's loss to the Chiefs, while Deebo Samuel is hospitalized with a form of ...

At an up-and-down 3-4, the reigning NFC champion San Francisco 49ers can't be reliably counted on as a bona fide contender.

San Francisco 49ers head coach Kyle Shanahan said Monday that All-Pro running back Christian McCaffrey has a chance to make ...